Sox21 and Hair Loss

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Baldness, receding hairlines and thinning hair can affect an individual regardless of sex and age.
Even though it is more common in men, women also suffer from excessive hair loss.
Different elements play vital roles in hair loss.
Environmental elements, strong medications, chemical hair treatments, diseases, unhealthy diets and lack of essential vitamins leading to serious malnutrition are some of the underlying factors that cause acute hair loss.
However, genetic framework of your family is equally important in determining hair loss and balding chances.
Recently scientists related a gene called Sox21 and hair loss.
Finding out the culprit gene is of major concern to find out whether it can affect the person and future generations.
• Many researchers found out that pattern baldness in male can be a hereditary condition.
Sensitivity towards DHT or dihydrotestosterone leads to this condition.
DHT is a male hormone or androgen, it is created from testosterone.
This sensitivity shortens and prevents hair growth.
It reduces the size of the hair follicle and produces thinner and finer hair.
If a man is genetically predisposed towards DHT sensitivity, he runs a higher chance of having spot baldness.
A man can inherit this sensitivity from either the father's or mother's side of his family.
• Though a man can acquire spot baldness from anyone of his parents, there is a higher chance of tracing the baldness link to his mother's side.
A new research suggests that a man possibly inherits his pattern baldness from his maternal relatives.
Male spot baldness is one of the sex-related characteristics.
Being passed from the mother to her child, a man can predict his probability of developing baldness just by studying his maternal relatives.
• All these traits are genetic but the particular gene responsible for carrying these features is thought to be Sox21.
• A group of researchers from Japan, while studying the effects of elimination of Sox21 gene in mice, were surprised to discover that the mice lost their body hair.
Sox21 was previously known to play an important part in nerve cell formation.
This new study indicates Sox21 gene's role in hair retention.
The scientists experimented on mice that carry this particular gene just like humans.
They found that if the activities of Sox21 were blocked in mice, the rodents at first started to lose hair and within a few weeks went completely hairless.
This breakthrough will help the scientists to link Sox21 and hair loss in humans.
It will help in pinpointing men who are prone to hair loss and develop innovative treatments.
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