Taking Blood Pressure Drugs at Night May Help Prevent Type 2 Diabetes
Study finds taking medication at night cut risk of blood sugar disorder in half
Drugs that target angiotensin include angiotensin receptor blockers (ARBs), ACE inhibitors and beta blockers. All three classes of medication were associated with a reduced risk of type 2 diabetes when taken at bedtime, the researchers found.
"This could be a very important study, which would influence how we treat high blood pressure in people with diabetes and people at risk for diabetes," Bloomgarden said. "These are some really interesting observations you can fit together into this idea that something's particularly going on at night."
After showing that reduced blood pressure during sleep was associated with lower risk of type 2 diabetes, the researchers decided to see whether taking an entire daily dose of one or more blood pressure medications at bedtime could drive a person's type 2 diabetes risk down even more.
The clinical trial involved more than 2,000 people who had high blood pressure but not diabetes. They were randomly assigned to take all their blood pressure medications either first thing in the morning or right before bed. During an average six-year follow up, 171 of the participants developed type 2 diabetes, the study said.
Study volunteers in the bedtime-treatment group experienced a significant reduction in their sleeping blood pressure, with "non-dipping" occurring in only 32 percent of their group, compared with 52 percent of the patients who took their medication in the morning, according to the study results.
The study found the risk of developing type 2 diabetes was 57 percent lower in the bedtime-treated group than the morning group after researchers adjusted for other complicating factors.
Specifically, the odds of type 2 diabetes dropped 61 percent for people taking angiotensin receptor blockers at bedtime compared to morning. For those on ACE inhibitors at night, the odds went down 69 percent. People on beta blockers reduced their odds of the blood sugar disease by 65 percent when they took their medicine at night, the researchers reported.
"Ingesting hypertension medications at bedtime, instead of upon awakening in the morning, improved asleep blood pressure control and markedly reduced the risk of [type 2] diabetes," Hermida said.
BP Drugs at Night May Help Prevent Type 2 Diabetes
Study finds taking medication at night cut risk of blood sugar disorder in half
Drugs that target angiotensin include angiotensin receptor blockers (ARBs), ACE inhibitors and beta blockers. All three classes of medication were associated with a reduced risk of type 2 diabetes when taken at bedtime, the researchers found.
"This could be a very important study, which would influence how we treat high blood pressure in people with diabetes and people at risk for diabetes," Bloomgarden said. "These are some really interesting observations you can fit together into this idea that something's particularly going on at night."
After showing that reduced blood pressure during sleep was associated with lower risk of type 2 diabetes, the researchers decided to see whether taking an entire daily dose of one or more blood pressure medications at bedtime could drive a person's type 2 diabetes risk down even more.
The clinical trial involved more than 2,000 people who had high blood pressure but not diabetes. They were randomly assigned to take all their blood pressure medications either first thing in the morning or right before bed. During an average six-year follow up, 171 of the participants developed type 2 diabetes, the study said.
Study volunteers in the bedtime-treatment group experienced a significant reduction in their sleeping blood pressure, with "non-dipping" occurring in only 32 percent of their group, compared with 52 percent of the patients who took their medication in the morning, according to the study results.
The study found the risk of developing type 2 diabetes was 57 percent lower in the bedtime-treated group than the morning group after researchers adjusted for other complicating factors.
Specifically, the odds of type 2 diabetes dropped 61 percent for people taking angiotensin receptor blockers at bedtime compared to morning. For those on ACE inhibitors at night, the odds went down 69 percent. People on beta blockers reduced their odds of the blood sugar disease by 65 percent when they took their medicine at night, the researchers reported.
"Ingesting hypertension medications at bedtime, instead of upon awakening in the morning, improved asleep blood pressure control and markedly reduced the risk of [type 2] diabetes," Hermida said.